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A deeper insight into mechanistic aspects is undoubtedly relevant for translational medicine, hoping that it could offer new strategies for these diseases in the next future.

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The major aims of the Research Topic are 1 to give a comprehensive view of the molecular mechanism underlying the different endocrine forms of arterial hypertension and 2 to offer a practical approach to the diagnosis and management of such diseases. Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Find out more on how to host your own Frontiers Research Topic or contribute to one as an author. Submission closed. Overview Articles Authors Impact Comments.

About this Research Topic Endocrine disorders associated with arterial hypertension account for a high proportion of cases of secondary hypertension. Keywords : Hypertension, Endocrine, Aldosterone, Cortisol, Adrenal Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements.

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Endocrine Hypertension, Hormone Imbalance

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This year-long, double-blind, placebo-controlled, randomized, crossover PATHWAY-2 trial was conducted at 12 secondary care sites and two primary care sites, all in the United Kingdom. Daily low dose spironolactone 25 to 50 mg added to s tandard blood pressure-lowering treatment was more effective than either placebo, or two alternative drugs studied —isoprolol and doxazosin.


As strong as the findings were, in order for the results of PATHWAY-2 to change practice, the researchers said, ''it was important to show a mechanistic basis underpinning the superiority of spironolactone. The researchers pursued an examination of whether amiloride could be an alternative if spironolactone was not tolerated due to side effects such as gynecomastia or erectile dysfunction. Mean baseline clinic blood pressure in the overall trial population was Baseline electrolytes and estimated glomerular filtration rate were normal; hour urinary sodium concentrations were about mmol equivalent to a 9 g of daily salt intake.

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The findings from these substudies also demonstrated that spironolactone was superior to other antihypertensive drugs in reducing indices of salt and water retention, that is, this medication promoted the reduction in blood pressure primarily by enhancing diuretic activity. While that study was not randomized, Dr. Brown indicated that the similar results were reassuring. Brown said; spironolactone was dosed at 25 mg and the dose of amiloride was 10 mg daily.

The nodule in the adrenal [if one is found] is churning out the aldosterone and causing the hypertension.


While the study was conducted in the UK, the findings would no doubt apply to the US population as well, Dr. Brown said. Calhoun has no relevant disclosures. Brown reports consulting fees from GSK, Mitsubishi-Europe, and Heptares, and the other study authors reported further financial disclosures.

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Email Print Discuss. Resistant Hypertension Explained By Underlying Endocrine Imbalance Researchers uncovered excess aldosterone as cause of antihypertensive treatment failure, and shed light on mechanisms to support breakthrough treatment success in resistant hypertension. Written by Kathleen Doheny. Resistant hypertension in